From /pol/ … on 11/7/2021
https://boards.4chan.org/pol/thread/346428460
Anonymous (ID: 5DwqVozC) 11/07/21(Sun)03:44:06 No.346429473
mRNA P1:
mRNA technology has been around for a while. What kept mRNA from being used in widespread vaccination was not having a way of protecting the mRNA long enough to get inside of cells and the ribosomes, where it can be “read” to construct a protein.
Instead of admitting this they (Moderna, Pfizer, etc.) went ahead with a lipid-soluble coating.
A lipid-soluble coating guarantees the injected mRNA to easily pass through cell membranes and get to the site of action (ribosomes). But it also meant that, unlike other vaccines, which have their particles taken up in normal lymph flow and end up in lymph-nodes, antigenic molecules are processed by dendritic cells and stay in the extracellular space (outside and in-between cells – the interstitium), otherwise the mRNA in these vaccines ends up everywhere, easily passing from the interstitium to the blood stream and across the blood-brain barrier.
Compared with getting a virus, the virus is only able to bond with and enter some cells; injecting its genetic material and taking over production to make more virus. It is limited to cells displaying molecules each virus is capable of binding to (in the case of SARS-CoV-2 this is a molecule called ACE2).
In “normal” vaccination only dendritic and a few other immune cells (which are designed to ingest and deal with antigenic molecules) end up with viral proteins in them. These specific cells are part of the immune reaction that ends up with long-term and robust immunity. With mRNA vaccination the injection is in the deltoid (most of the time) but the particles of mRNA move easily move in and out of cells and across biological membranes. Any cell, and subsequently its ribosomes, which come into contact with the exogenous mRNA, will start to produce the altered SARS-CoV-2 spike proteins that the mRNA instructs for.
mRNA P2:
In the normal course of cellular function the master copy of your build and operating instructions (DNA) has a chapter photocopied as needed (mRNA) and sent out to factories (ribosomes) which read the instructions and build proteins according to them. During this process, whatever protein is being made is reported back to the immune system. This happens by each of your cells taking one of the things its ribosomes are making and displaying them on the outside of their cell membrane.
Security (T-Cells of the immune system) come by, but can’t get inside, they just look at the sign to see if something is off. If something is, they can nuke the whole city (induce lysis) or tag the sign for other bulldozer immune cells to come by and level it. This function fights both cancer and viral infection.
If either of those things cause a cell to start making abnormal or foreign proteins then the cell is instructed to kill itself (lysis) or it gets tagged to be destroyed by other immune cells.
mRNA P3:
Until recently you could only end up with antigenic (things which set off an immune response) molecules displayed to the immune system on subsets of cells. Either a virus infected your cells and that virus could only attach and enter a tiny number of overall cells in your body (like SARS-CoV-2 and cells which display ACE2), or you could get cancer (which is essentially one cell over and over and over).
Outside of that, antigenic molecules would be immediately destroyed by natural killer cells or would be collected through lymph to be processed and displayed by dendritic cells in lymph tissue (lymph nodes mostly). These dendritic cells look like massive tree root systems and all they do is process foreign material and display it on Major Histocompatibility Complex. That’s the molecule complex that announces what’s going on inside a cell to the outside world. It is the security (the immune system) that monitors to know if there is an issue inside, as security is a cell itself, and can’t enter another cell.
The immune system is blind to the intracellular environment besides these signs (MHC). One type of T-Cell, T-Helper Cells, move up and down the “root system” of the dendritic cell, just looking at all the signs.
In this way, your lymph nodes and spleen (where this process mostly happens) act as security checkpoints, eventually coming across fragments of anything that ends up in your body. If they find something wrong, they induce an immune response to that thing which will eventually reach wherever the molecules they saw came from.
mRNA P4:
By injecting these lipid-soluble mRNA particles into peoples bodies; littering them throughout all tissue, dependent on each individuals weight, lipid percentage, hydration, cardiovascular state, anatomy, etc. Wherever concentrations of these end up you have random cells which will start to produce altered spike proteins.
The immune system notices this and starts attacking those areas. As each mRNA vaccinated cell is destroyed they spill their contents of altered spike protein (cytotoxic itself) into the local area.
The vaccine makers know the path to immune activation is through MHC (signs), and don’t really address or care about all the excess spike proteins being made.
In the background, ribosomes are churning out actual spike protein into the inside of the cell. This is how viruses reproduce as well; once infected more viral particles are constructed inside a cell, but they don’t get to release and go infect other cells until the infected cell is destroyed and they can escape.
mRNA P5:
All the atoms in your body are replaced about once a decade. Even your bones are constantly re-structured by osteoclasts and osteoblasts, so every 10 years you have entirely different atoms making up those bones. Even cells that generally don’t replicate or die until you do, like neurons and muscle constantly replace their constituent parts.
The MHC displaying the product the ribosome are making will stay embedded in the cell wall until that section of the membrane is replaced due to other natural process (e.g. endocytosis).
This means that people who end up with persistent neurological or cardiac side effects may have them for years, until most of the signs stating the cell is making spike protein are torn down. For neurons in the brain, that could be years, not to mention the fact that in the mean time, the immune system is actively trying to kill off any of those cells, and often successfully.
There is so much we don’t understand about this. A gigantic portion of your genome is dedicated to MHC. We don’t have any idea about the mechanisms we are playing with. Not only are large swaths of MHC black boxes but the whole question of Clonal Selection (how your body ‘knows’ what is you and what isn’t you, and therefore what to attack) is an open question.
There are no longitudinal studies on any of this, the safety data is non-existent beyond “it probably doesn’t kill many of you in the first 90 days.” It will take years to collect the data and produce irrefutable results, which is why the normal process is around 6 years from a working product. Without control groups, even that data will be easy to skew in interpretation though.
Specific vaccines: The artificially produced spike protein vaccines all have the shortcomings of the mRNA vaccines (small spectrum of antibodies induced and a lack of robust long-term immunity), but they don’t result in the widespread MHC/spike protein complexes outside the immune system.
Instead of littering mRNA throughout all cells randomly the viral vector vaccines can only get mRNA to the cells they can infect. It was thought this would be a harmless subset of cells that wouldn’t generally be directed to a specific tissue and cause isolated problems.
Instead, the adenovirus carrier seems to be related specifically to infections of the epithelial lining of blood vessels. That’s where the idea of “COVID being a blood vessel disease” came from and the claim that clots were from “roughing up of vascular walls.” That’s not the case, blood clots are from altered spike protein / antibody complex agglutinations lodging in distal vasculature and inducing the compliment system which results in clots. The specific adenoviral vector may be targeting blood vessels and causing clots in that subset of patients as well though.
We’ve been trying to make a vaccine to this type of thing for decades and always failed. SARS-CoV-1, H5N1, MERS, Influenza, no vaccine. What is the magical breakthrough that we had last year that changed everything and made these virus classes so easy to vaccinate for? Nothing, they are lying to everyone.
The viral vector vaccine(s) (Novavax) are no better than the mRNA vaccines, they bring their own set of problems.
The inactivated and attenuated vaccine(s) (Valneva) are unlikely to work as we’ve been trying them for years against coronaviruses, influenza, and any other respiratory virus we can find, and they never work, so the safety of them should be on par with past vaccines.
Novavax is better than mRNA in theory, because it’s injecting artificial spike proteins. But at the end of the day, you’ll still need more shots.
The path to robust long-lasting immunity is through a broad spectrum of antigenic sites, only the spike protein is never going to do it, it’s all just induced antibody therapy.
The Sinovac vaccine is an inactivated viral vaccine. The Chinese haven’t made information on it readily available.
But inactivated viral vaccines have been tried for decades against common cold corona virus and influenza (to name a few) and other respiratory viruses (MERS) and they never worked. To make them more effective they have taken to upping the dose to massive levels. This causes more of an immune reaction, but also skyrockets the rate of adverse events.
The Valneva vaccine is an inactivated, adjuvanted whole virus vaccine. This is the “classic” vaccine technology and doesn’t seem to have any new risks associated with it.
This strategy has been extensively attempted against seasonal respiratory virus for decades and has failed, so I am suspect of its long-term efficacy (which is a good thing in this case because the immune system needs to handle this). It has none of the associated safety concerns with the mRNA vaccines.
Other points: These vaccines also have no hope of imparting robust long term immunity, and are effectively short-term antibody therapy to one specific part of one specific strain. You need to have a broad spectrum of antigenic sites to induce robust and long lasting immunity. That’s why vaccines are more complicated than re-producing a single bacterial protein and rubbing it on a cut. Although, doing that with dead bacteria (scabs) is where we saw inoculation first work.
Whether the vaccines were attenuated, destroyed, or dead, the only vaccines we have ever seen impart robust and long lasting immunity provided the whole host of antigenic particles found in the wild. It’s another reason why mRNA wasn’t in widespread use in addition to the technical problem of a protective coating or encapsulation.
And more shots are being mandated to keep “antibody levels” high, even though high antibody levels are a sign of infection, not immunity. Antibody levels should fade quickly and be replaced with primed memory cells.
These mRNA “vaccines” don’t work and nor can they be considered vaccines. Mild endogenous antibody therapy would be a better description, which is why they had to change the definition of vaccine. They will only ever produce widespread, diffuse and low level specific signals.
This is a totally abnormal use of mRNA. It’s more akin to hacking software than it is to a biological process.
The mRNA particles are little snippets of code. Each one is identical, without a qualitative factor. Genetics is a pure information system (coded as DNA); you can write the spike protein down and not lose any fidelity. There are no known mechanisms in the wild that would monitor or react to what we are doing.
The best option is to not have the mRNA injected into you in the first place. Once it is, all you can do is max out your nutrition, hydration, exercise, vitamins, and other micro-nutrients and supplements, etc. The body will eventually clear the mRNA (short-term weeks), the induced spike proteins (mid-term months), and the MHC bound induced spike protein (long-term years.) It’s just a matter of surviving until it does.
The mRNA vaccines being used right now have not been seen getting transcribed into DNA and incorporated into the human genome. A mechanism for that has been discussed in theory in one paper out of MIT, which provides a logical framework of how that could happen. It requires the presence of HIV reverse transcriptase though, which isn’t around for most people.
Reverse transcription of an RNA virus into DNA and its subsequent inclusion in peoples DNA in a persistent manner is probably not happening. That’s why continued shots are required, the immune system is, eventually, successful in clearing the mRNA, the free altered spike proteins induced by it, and the MHC / membrane bound altered spike proteins in vaccinated cells. The “side-effects” are the immune system clearing all that and damaging you in the process.
If you survive that, then there should be no long-term changes, other than the damage done in the process. If you cleared all the vaccine products, and don’t have tissue damage that’s permanent, then you won’t have any long-term alterations from the mRNA vaccines.
To be clear, there is no mechanism for these mRNA vaccines to change anything permanently about you. The exception is of course the damage your immune system does in the process of clearing vaccinated cells. If you get brain damage from the process, that’s not going to be repaired once you clear the vaccine by-products. But if you make it through vaccination unscathed then there is nothing inherent in the mRNA vaccine that will affect you long term.
From the time you get the mRNA vaccine it’s a race to clear all the by-products before the process of clearing the by-products causes significant damage. When you get another shot you start from square one again.
The vaccinated do shed the altered spike protein, but realistically it shouldn’t be more harmful than any other antigen. If you were in sexual contact with a vaccinated person then you might come into contact with enough to induce a noticeable immune response and feel bad for a day or two.
There’s no mechanism to incorporate those shed altered spike proteins into cells in the non-vaccinated though, so your immune system is well suited to removing them.
For all the dangers and unknowns of the mRNA vaccines, none of it results in robust and long-lasting immunity.
What we have is a perfect environment for the virus to rapidly avoid the limited spectrum of antibodies our vaccination programs are largely producing. Delta is just the start if we keep this up.
Blood clots: The blood clots seem to be from agglutinations lodging in distal vasculature.
The mRNA gets the spike protein into MHC and T cells, but it also induces the production of massive amounts of spike protein that get dumped into tissue when the vaccinated cell is destroyed. The vaccinated cell will be destroyed because the immune system thinks it’s infected by SARS-CoV-2 based on what’s in its MHC. At that point, the antibodies do what they are meant to, they attach to the artificially produced spike protein, clumping it together.
Antibody ends are Y shaped, so they stick to multiple antigen and multiple antibodies attach to each, so you get large, sticky, “agglutinations” of antibody-antigen complex. The common end of the antibodies induces platelet aggregation through activation of the compliment system, inducing a clot wherever that happens.
Myocarditis: Myocarditis itself means inflammation of the myocardium (heart muscle). So, you can have it from a host of things.
Bacterial myocarditis, viral myocarditis, rheumatoid (immune) myocarditis, etc. This is closest to rheumatoid myocarditis but different, in normal rheumatoid myocarditis there is a problem in clonal selection and your body makes immune cells that seek out myocardium and attack it, causing inflammation. In this case, mRNA is inducing these cells to signal to the immune system that they are infected with SARS-Cov-2 and need to be destroyed. The immune system obliges and causes inflammation. Inflammation is an emergent trait of a bunch of things the immune system does at the site of an infection to fight it more effectively.
Myocarditis will also occur in people with lower body fat percentages (i.e. “fit young men”), so fat people, while already predisposed to weakness, are somewhat protected by their fat from vaccine induced myocarditis due to significantly increased lipid content in their body.
ADE: ADE is a major concern, and it seems like we are seeing strong signals that it’s a thing. There is also an ongoing risk of creating prions, which we effectively know nothing about. Right now, there isn’t clear enough data to draw any mainstream attention. But ADE is real and seems to be happening at some level. Prions, if they happen, well nothing will matter, that’s the end of us.
(A prion is a misfolded protein that causes other proteins, that they come into contact with, to misfold as well. This is very bad news because it behaves like an infectious disease. It slowly converts all the proteins in your body to the misfolded shape, and your body slowly stops working like a clock that has all its clockwork replaced with non-working parts).
As far as other things to look out for, it’s hard to say. It also depends on the person in question, their size, hydration, circulation, fat content, etc.
INFECTIOUS DISEASE: Mutant Strains Of Polio Vaccine Now Cause More Paralysis Than Wild Polio – June 28, 20173:22 PM ET
Natural immunity is the gold standard of immunity. All inoculations and immunizations try to mimic what natural immunity is. If natural immunity isn’t the best possible immunity, then none of the theory behind any vaccine makes sense.
When coming into contact with a virus naturally you are exposed to all possible antigenic sites from inside and outside the virus at all stages of its development.
One of the keys to inducing immune memory is a broad spectrum of antigenic sites, the only way to get this completely is from a naturally occurring virus. If you are under 65 and are not morbidly obese or with a serious co-morbid medical condition, you have no risk and natural immunity is the logical choice.
There’s nothing as effective as being naturally exposed to the full sectrum of antigenic sites that a real virus has. The tiny spectrum of antibodies created in response to just spike proteins have no hope of inducing robust and long-lasting immunity, only natural immunity can do that, hence forever booster shots.
Vaccines only hinder or prevent a natural process that exists to make us stronger. All vaccines weaken you no matter any immediate benefits.
Immunity can only be achieved by transmitting without vaccination. Thus, immunity comes from your immune system. Those few predisposed to vulnerability may be treated accordingly so long as they accept that their immune system is compromised by artificial means, and that they pose a risk to the group.
The specialist thesis is that we don’t know about these mechanisms, in addition to where we know problems can arise. The prognosis for most is probably mild side-effects that clear up relatively quickly (months if not weeks). Some unknown percentage will end up with a random host of what looks like auto-immune disease for up to a decade. The signals of any specific ailment will be hidden because the vaccine mRNA coating is so lipid soluble that the mRNA can end up anywhere in your body. Where it happens to end up in each person will determine the specifics, degree, and length of any side-effects.
The virus and the vaccine are insanity. The West has been researching and planning for a pandemic for a hundred years. All of that has been thrown out the window with news celebrities and politicians calling the shots. This has nothing to do with medicine or public health. This has to do with dividing the population along the line of compliant or non-compliant.
If you have serious comorbidity you may want to consider the inactivated or attenuated viral vaccines (Valneva). At that point it’s a personal choice, if your health is that precarious then it’s not that SARS-CoV-2 got you, it’s that literally anything you get next will kill you.
That’s it.
